abstract：:This commentary considers modulation as a factor of potential biological importance in assessment of risk of radiofrequency (RF) energy emitted by communications systems and other technologies. Modulation introduces a spread of frequencies into a carrier waveform, but in nearly all cases this spread is small compared ...

journal_title：Radiation research

authors： Foster KR,Repacholi MH

更新日期：2004-08-01 00:00:00

abstract：:Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...

journal_title：Radiation research

authors： Latre L,Genescà A,Martín M,Ribas M,Egozcue J,Blasco MA,Tusell L

更新日期：2004-08-01 00:00:00

abstract：:We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas ...

journal_title：Radiation research

authors： Berrada M,Yang Z,Lehnert SM

更新日期：2004-07-01 00:00:00

abstract：:Trp53 heterozygous mice are radiation-sensitive and cancer-prone. Groups of 7-8-week-old female Trp53 heterozygous mice were exposed to 4 Gy of 60Co gamma radiation at high (0.5 Gy/min) or low (0.5 mGy/min) dose rate. Other groups received 10 or 100 mGy at low dose rate 24 h prior to the 4-Gy dose. Tumor frequency and...

journal_title：Radiation research

authors： Mitchel RE,Jackson JS,Carlisle SM

更新日期：2004-07-01 00:00:00

abstract：:Radiation-induced endothelial cell apoptosis is involved in the development of many radiation injuries, including radiation-induced skin ulcers. The proangiogenic growth factors basic fibroblast growth factor (bFGF, NUDT6) and VEGF enhance endothelial cell survival. In the present study, we used primary cultured human...

journal_title：Radiation research

authors： Gu Q,Wang D,Wang X,Peng R,Liu J,Jiang T,Wang Z,Wang S,Deng H

更新日期：2004-06-01 00:00:00

abstract：:Bcl-X(S) is a pro-apoptosis member of the Bcl2 family that has been shown to induce cell death and enhance chemosensitivity. We have investigated the effect of Bcl-X(S) overexpression on radiation sensitivity. Using a tetracycline-repressible system, we found that removal of tetracycline for 16 h induced Bcl-X(S) and ...

journal_title：Radiation research

authors： Morgan MA,Poynter JN,Maybaum J,Lawrence TS

更新日期：2004-05-01 00:00:00

abstract：:The physical and biological basis of our model to calculate the biological effects of charged particles, termed the local effect model (LEM), has recently been questioned in a commentary by R. Katz. Major objections were related to the definition of the target size and the use of the term cross section. Here we show t...

journal_title：Radiation research

authors： Scholz M,Kraft G

更新日期：2004-05-01 00:00:00

abstract：:We have previously observed time- and dose-dependent increases in matrix metalloproteinase 2 (Mmp2) protein levels in rat tubule epithelial cells (NRK52E) after irradiation. However, the mechanism(s) involved remains unclear. In the present study, irradiating NRK52E cells with 0-20 Gy gamma rays was associated with ti...

journal_title：Radiation research

authors： Zhao W,Goswami PC,Robbins ME

更新日期：2004-04-01 00:00:00

abstract：:We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated ...

journal_title：Radiation research

authors： Asakawa J,Kuick R,Kodaira M,Nakamura N,Katayama H,Pierce D,Funamoto S,Preston D,Satoh C,Neel JV,Hanash S

更新日期：2004-04-01 00:00:00

abstract：:This review highlights the phenomenon of low-dose hyper- radiosensitivity (HRS), an effect in which cells die from excessive sensitivity to small single doses of ionizing radiation but become more resistant (per unit dose) to larger single doses. Established and new data pertaining to HRS are discussed with respect to...

journal_title：Radiation research

authors： Marples B,Wouters BG,Collis SJ,Chalmers AJ,Joiner MC

更新日期：2004-03-01 00:00:00

abstract：:There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sa...

journal_title：Radiation research

authors： Cheda A,Wrembel-Wargocka J,Lisiak E,Nowosielska EM,Marciniak M,Janiak MK

更新日期：2004-03-01 00:00:00

abstract：:To determine whether exposure to radiofrequency (RF) radiation can induce DNA damage or apoptosis, Molt-4 T lymphoblastoid cells were exposed with RF fields at frequencies and modulations of the type used by wireless communication devices. Four types of frequency/modulation forms were studied: 847.74 MHz code-division...

journal_title：Radiation research

authors： Hook GJ,Zhang P,Lagroye I,Li L,Higashikubo R,Moros EG,Straube WL,Pickard WF,Baty JD,Roti Roti JL

更新日期：2004-02-01 00:00:00

abstract：:Therapeutic irradiation of the brain can cause a progressive cognitive dysfunction that may involve defects in neurogenesis. In an effort to understand the mechanisms underlying radiation-induced stem cell dysfunction, neural precursor cells isolated from the adult rat hippocampus were analyzed for acute (0-24 h) and ...

journal_title：Radiation research

authors： Limoli CL,Giedzinski E,Rola R,Otsuka S,Palmer TD,Fike JR

更新日期：2004-01-01 00:00:00

abstract：:Current and potential shortfalls in the number of radiation scientists stand in sharp contrast to the emerging scientific opportunities and the need for new knowledge to address issues of cancer survivorship and radiological and nuclear terrorism. In response to these challenges, workshops organized by the Radiation R...

journal_title：Radiation research

authors： Coleman CN,Stone HB,Alexander GA,Barcellos-Hoff MH,Bedford JS,Bristow RG,Dynlacht JR,Fuks Z,Gorelic LS,Hill RP,Joiner MC,Liu FF,McBride WH,McKenna WG,Powell SN,Robbins ME,Rockwell S,Schiff PB,Shaw EG,Siemann DW,Tr

更新日期：2003-12-01 00:00:00

abstract：:The (11)B(p,alpha)(8)Be* nuclear reaction was assessed for its ability to quantitatively map the in vivo subcellular distribution of boron within gliosarcomas treated with a boronated neutron capture therapy agent. Intracranial 9L gliosarcomas were produced in Fischer 344 rats. Fourteen days later, the majority of the...

journal_title：Radiation research

authors： Bench G,Grant PG,Ueda DL,Autry-Conwell SA,Hou Y,Boggan JE

更新日期：2003-12-01 00:00:00

abstract：:Proteinase-activated receptor 2 (Par2, F2rl1, also designated PAR-2 or PAR2) is prominently expressed in the intestine and has been suggested as a mediator of inflammatory, mitogenic and fibrogenic responses to injury. Mast cell proteinases and pancreatic trypsin, both of which have been shown to affect the intestinal...

journal_title：Radiation research

authors： Wang J,Zheng H,Hollenberg MD,Wijesuriya SJ,Ou X,Hauer-Jensen M

更新日期：2003-11-01 00:00:00

abstract：:Infusions of boronophenylalanine-fructose complex (BPA-F), at doses up to 900 mg/kg of BPA and 860 mg/kg of fructose, have been used to deliver boron to cancer tissue for boron neutron capture therapy (BNCT). In patients with phenylketonuria (PKU), phenylalanine accumulates, which is harmful in the long run. PKU has b...

journal_title：Radiation research

authors： Laakso J,Ruokonen I,Lapatto R,Kallio M

更新日期：2003-11-01 00:00:00

abstract：:To evaluate whether DNA alterations in mature spermatozoa could stem from DNA damage induced in immature germ cells, testis cells and spermatozoa were analyzed by the comet assay and by the sperm chromatin structure assay 14, 45 and 100 days after in vivo X irradiation of the testes. These times were selected, accordi...

journal_title：Radiation research

authors： Cordelli E,Fresegna AM,Leter G,Eleuteri P,Spanò M,Villani P

更新日期：2003-10-01 00:00:00

abstract：:Involvement of gap junctional intercellular communication (GJIC) in bystander responses of confluent human fibroblasts irradiated with a carbon-ion beam was investigated. It was found that the lower the radiation dose, the higher the yield of radiation-induced micronuclei per nuclear traversal, suggesting the existenc...

journal_title：Radiation research

authors： Shao C,Furusawa Y,Aoki M,Ando K

更新日期：2003-09-01 00:00:00

abstract：:Soil microorganisms in general and biocontrol agents in particular are very sensitive to UV light. The packaging of biocontrol microorganisms into cellular solids has been developed as a means of reducing loss caused by exposure to environmental UV radiation. The bacterial and fungal biocontrol agents Pantoea agglomer...

journal_title：Radiation research

authors： Zohar-Perez C,Chernin L,Chet I,Nussinovitch A

更新日期：2003-08-01 00:00:00

abstract：:Clinicians involved in conventional radiation therapy are very concerned about the dose-response relationships of normal tissues. Before proceeding to new clinical protocols, radiation biologists involved with conformal proton therapy believe it is necessary to quantify the dose response and tolerance of the organs an...

journal_title：Radiation research

authors： Kubínová L,Mao X,Janácek J,Archambeau JO

更新日期：2003-07-01 00:00:00

abstract：:To estimate the effect of 50 Hz magnetic-field exposure on genome-wide gene expression, the yeast Saccharomyces cerevisiae was used as a model for eukaryotes. 2D PAGE (about 1,000 spots) for protein and cDNA microarray (about 5,900 genes) analysis for mRNA were performed. The cells were exposed to 50 Hz vertical magne...

journal_title：Radiation research

authors： Nakasono S,Laramee C,Saiki H,McLeod KJ

更新日期：2003-07-01 00:00:00

abstract：:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 typ...

journal_title：Radiation research

authors： Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Y

更新日期：2003-06-01 00:00:00

abstract：:The immunocytochemical response to DNA damage induced by low-energy bismuth and carbon ions was investigated in normal human fibroblasts. Inside the nuclei, the traversing charged particles lead to the accumulation of proteins related to DNA lesions and repair along the ion trajectories. Irradiation under a standard g...

journal_title：Radiation research

authors： Jakob B,Scholz M,Taucher-Scholz G

更新日期：2003-05-01 00:00:00

abstract：:The mechanisms underlying the hyper-radiosensitivity of AT cells were investigated by analyzing chromosome aberrations in the G(2) and M phases of the cell cycle using a combination of chemically induced premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with chromosome painting prob...

journal_title：Radiation research

authors： Kawata T,Ito H,George K,Wu H,Uno T,Isobe K,Cucinotta FA

更新日期：2003-05-01 00:00:00

abstract：:It was reported by others that hands-free accessories increase the absorption of RF energy in a human head compared to a handset alone. The results of this study show that the opposite is observed when proper dosimetric methods are employed. It is pointed out that for correct estimation of the exposure level it is nec...

journal_title：Radiation research

authors： Bit-Babik G,Chou CK,Faraone A,Gessner A,Kanda M,Balzano Q

更新日期：2003-04-01 00:00:00

abstract：:Mitochondrial DNA heteroplasmy using the protein-coding cytochrome b (Mtcyb) gene was assessed in laboratory mice (C57BL/6 and BALB/c) exposed to the Chernobyl environment. Subacute to subchronic (30-40 days) exposure resulted in a cumulative radiation dose of 1.2-1.6 Gy ( approximately 0.04 Gy/day). Mice were sampled...

journal_title：Radiation research

authors： Wickliffe JK,Rodgers BE,Chesser RK,Phillips CJ,Gaschak SP,Baker RJ

更新日期：2003-04-01 00:00:00

abstract：:Alteration of the radiation-induced changes in wound contraction, collagen synthesis and wound histology by ascorbic acid was studied in mice exposed to 10, 16 and 20 Gy of fractionated (2 Gy/fraction) gamma radiation. The animals were given double-distilled water or ascorbic acid daily before exposure to 2 Gy/day of ...

journal_title：Radiation research

authors： Jagetia GC,Rajanikant GK,Rao SK

更新日期：2003-03-01 00:00:00

abstract：:Chromatid breaks have previously been shown to be induced in G2-phase cells after exposure to ionizing radiation (X and gamma rays) as a linear function of dose, consistent with a single-event mechanism. DNA double-strand breaks (DSBs) are thought to be the initiating lesion, and experiments with a genetically enginee...

journal_title：Radiation research

authors： Bryant PE,Jones C,Armstrong G,Frankenberg-Schwager M,Frankenberg D

更新日期：2003-02-01 00:00:00

abstract：:The high-energy neutron component of the space radiation environment in thick structures such as the International Space Station contributes to the total radiation dose received by an astronaut. Detector design constraints such as size and mass have limited the energy range of neutron spectrum measurements in orbit to...

journal_title：Radiation research

authors： Kinnison JD,Maurer RH,Roth DR,Haight RC

更新日期：2003-02-01 00:00:00

abstract：:Through a detailed study of cell cycle progression, protein expression, and kinase activity in gamma-irradiated synchronized cultures of human skin fibroblasts, distinct mechanisms of initiation and maintenance of G2-phase and subsequent G1-phase arrests have been elucidated. Normal and E6-expressing fibroblasts were ...

journal_title：Radiation research

authors： DeSimone JN,Bengtsson U,Wang X,Lao XY,Redpath JL,Stanbridge EJ

更新日期：2003-01-01 00:00:00

abstract：:The induction of chromosome aberrations in human lymphocytes irradiated in vitro with X rays generated at a tube voltage of 29 kV was examined to assess the maximum low-dose RBE (RBE(M)) relative to higher-energy X rays or 60Co gamma rays. Since blood was taken from the same male donor whose blood had been used for pr...

journal_title：Radiation research

authors： Schmid E,Regulla D,Kramer HM,Harder D

更新日期：2002-12-01 00:00:00

abstract：:To compare the genotoxic effects of high-LET ionizing radiation to those of low-LET radiation, we investigated the responses of human lymphoblastoid cells to DNA damage TK6 after treatment with either low-LET X rays or high-LET iron ions (1000 keV/microm). A highly localized distribution of gammaH2AX/RAD51 foci was ob...

journal_title：Radiation research

authors： Goto S,Watanabe M,Yatagai F

更新日期：2002-12-01 00:00:00

abstract：:Human immortalized keratinocytes were exposed to a range of single or fractionated doses of gamma rays from (60)Co, to medium harvested from donor cells exposed to these protocols, or to a combination of radiation and irradiated cell conditioned medium (ICCM). The surviving fractions after direct irradiation or exposu...

journal_title：Radiation research

authors： Mothersill C,Seymour CB

更新日期：2002-11-01 00:00:00

abstract：:Human blood cultures were exposed to a 1.9 GHz continuous-wave (CW) radiofrequency (RF) field for 2 h using a series of six circularly polarized, cylindrical waveguides. Mean specific absorption rates (SARs) of 0.0, 0.1, 0.26, 0.92, 2.4 and 10 W/kg were achieved, and the temperature within the cultures during a 2-h ex...

journal_title：Radiation research

authors： McNamee JP,Bellier PV,Gajda GB,Miller SM,Lemay EP,Lavallée BF,Marro L,Thansandote A

更新日期：2002-10-01 00:00:00

abstract：:Three somatic mutation assays were evaluated in men exposed to low-dose, whole-body, ionizing radiation. Blood samples were obtained between 1992 and 1999 from 625 Russian Chernobyl cleanup workers and 182 Russian controls. The assays were chromosome translocations in lymphocytes detected by FISH, hypoxanthine phospho...

journal_title：Radiation research

authors： Jones IM,Galick H,Kato P,Langlois RG,Mendelsohn ML,Murphy GA,Pleshanov P,Ramsey MJ,Thomas CB,Tucker JD,Tureva L,Vorobtsova I,Nelson DO

更新日期：2002-10-01 00:00:00

abstract：:Previous work showed that treatment of plateau-phase Chinese hamster ovary cells with the radiomimetic double-strand cleaving agent bleomycin induced very small deletions as well as interchromosomal reciprocal translocations, both of which could be ascribed to errors in end joining of DNA double-strand breaks. In an a...

journal_title：Radiation research

authors： Yu Y,Inamdar KV,Turner K,Jackson-Cook CK,Povirk LF

更新日期：2002-09-01 00:00:00

abstract：:A yeast-based frameshift/stop codon assay for examining ATM (ataxia telangiectasia mutated) mutations was established. Each of six fragments of a PCR-amplified coding sequence for ATM is inserted in frame by homologous recombination into a yeast URA3 fusion protein gene, and the transformants are assayed for growth in...

journal_title：Radiation research

authors： Tsuchida R,Yamada T,Takagi M,Shimada A,Ishioka C,Katsuki Y,Igarashi T,Chessa L,Delia D,Teraoka H,Mizutani S

更新日期：2002-08-01 00:00:00

abstract：:The ability of the aminothiol WR-1065 [N-(2-mercaptoethyl)-1,3-diaminopropane] to protect L5178Y (LY) cells against the cytotoxic and mutagenic effects of exposure to accelerated (56)Fe ions (1.08 GeV/nucleon) was determined. It was found that while WR-1065 reduced the mutagenicity in both cell lines when it was prese...

journal_title：Radiation research

authors： Evans HH,Evans TE,Horng MF

更新日期：2002-07-01 00:00:00

abstract：:We present measurements of low-energy (<18 eV) electron-stimulated desorption of anions from acetamide (CH(3)CONH(2)) and dimethyl disulfide [DMDS: (CH(3)S)(2)] films. Electron irradiation of physisorbed CH(3)CONH(2) produces H(-), CH(3)(-) and O(-) anions, whereas the H(-), CH(2)(-), CH(3)(-), S(-), SH(-) and SCH(3)(...

journal_title：Radiation research

authors： Abdoul-Carime H,Cecchini S,Sanche L

更新日期：2002-07-01 00:00:00